Pathophysiological aspects of coxsackievirus B intestinal infection13

نویسندگان

  • Roger M. Loria
  • Selwyn A. Broitman
چکیده

Relatively little is known about the pathophysiological events that are associated with viral enteric infections. The susceptibility of the adult mouse to infection with group B coxsackievirus and the absence of clinical manifestations in this host indicated that this would make a useful model for studying such events. The marked similarities between infection with this agent in the mouse and man, moreover, suggested that the results of such studies might also have application to man. Accordingly, mice infected perorally (po) or intrapenitoneally ( ip) with a group B coxsackievirus were examined for the effects of such infection on glucose and leucine absorption from the gut. In addition, the effects on epithelial cell division and migration rate in the gut were determined.

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تاریخ انتشار 2005